Cognitive clusters in first-episode psychosis: Overlap with healthy controls and relationship to concurrent and prospective symptoms and functioning

J Uren; SM Cotton; E Killackey; MM Saling; K Allott

Journal article

Cognitive clusters in first-episode psychosis: Overlap with healthy controls and relationship to concurrent and prospective symptoms and functioning

J Uren, SM Cotton, E Killackey, MM Saling, K Allott

Neuropsychology | AMER PSYCHOLOGICAL ASSOC | Published : 2017

DOI: 10.1037/neu0000367

Abstract

Objective: To identify cognitive subgroups (comprising neurocognition and social cognition domains) within first-episode psychosis (FEP) patients including a healthy control group for comparison. Predictive validity of cognitive clusters in relation to symptoms and functioning was also investigated. Method: A comprehensive cognitive battery was administered to 133 FEP participants and 46 healthy controls. Ward's method hierarchical agglomerative cluster analysis with k-means verification was used to determine clusters. Clusters were externally validated and 6-month predictive validity was also examined. Results: Three distinct clusters were identified and were defined by degree of impairment..

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University of Melbourne Researchers

Susan Cotton Author

Eoin Killackey Author

Michael Saling Author

Kelly Allott Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

Kelly Allott is funded by a Ronald Philip Griffiths Fellowship, University of Melbourne. Eoin Killackey is supported by a National Health and Medical Research Council Career Development Fellowship (CDF-II APP1051891). Susan M. Cotton is supported by a National Health and Medical Research Council Career Development Fellowship (CDF, APP1061998). The data collection in the original study was funded by an ARC Linkage Grant (LP0883237) as well as funding from the Australian Rotary Health Research Fund.